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TICKERS: AVXL

Ph1 Trial Results of Dementia Drug Positive
Research Report

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The Quick Take

  • Dawson James has a Buy rating and a $35 per share price target on Anavex Life Sciences.
  • Dawson James ranks Anavex Life Sciences Buy on promising clinical trial results of Anavex 3-71 in frontotemporal dementia.
  • The Phase 1 study results showed Anavex 3-71 to be safe and well tolerated, reported Dawson James analyst Jason Kolbert in a Jan. 11 research note.
  • Pharmacokinetics of Anavex 3-71 were shown to be the same regardless of gender and food intake.
  • Anavex 3-71 is an oral small molecule agonist of both SIGMAR1 and cholinergic receptor muscarinic M1 and has orphan drug designation in the U.S.
  • Anavex Life Sciences plans another trial of Anavex 3-71, in frontotemporal dementia, schizophrenia, and Alzheimer's disease, to commence in 2022.

The results of Anavex Life Sciences Corp.'s (AVXL:NASDAQ) Phase 1 Anavex 3-71 study suggest "a promising pipeline" for the drug candidate, purported Dawson James analyst Jason Kolbert.

In this trial, participants comprising different cohorts received single doses of Anavex 3-71 between 5 and 200 milligrams daily. No adverse events were reported, and lab tests showed no abnormalities. There were no clinically significant electrocardiogram parameters.

The biopharma indicated the next step for Anavex 3-71 is another clinical trial, this one evaluating the longitudinal effect of treatment with this therapeutic candidate in three neurodegenerative diseases, noted Kolbert.

"Anavex believes the results of this [next] study could serve as the basis for advancing into respective registration studies in the U.S.," Kolbert wrote.

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Disclosures for Dawson James Securities Inc., Anavex Life Sciences Corp., Jan. 11, 2022

Dawson James Securities, Inc. (the "Firm") is a member of the Financial Industry Regulatory Authority ("FINRA") and the Securities Investor Protection Corporation ("SIPC").
The Firm does not make a market in the securities of the subject company(s). The Firm has NOT engaged in investment banking relationships with AVXL in the prior twelve months, as a manager or co-manager of a public offering and has NOT received compensation resulting from those relationships. The Firm may seek compensation for investment banking services in the future from the subject company(s). The Firm has NOT received any other compensation from the subject company(s) in the last 12 months for services unrelated to managing or co-managing of a public offering.
Neither the research analyst(s) whose name appears on this report nor any member of his (their) household is an officer, director or advisory board member of these companies. The Firm and/or its directors and employees may own securities of the company(s) in this report and may increase or decrease holdings in the future. As of December 31, 2021, the Firm as a whole did not beneficially own 1% or more of any class of common equity securities of the subject company(s) of this report. The Firm, its officers, directors, analysts or employees may affect transactions in and have long or short positions in the securities (or options or warrants related to those securities) of the company(s) subject to this report. The Firm may affect transactions as principal or agent in those securities.
Analysts receive no direct compensation in connection with the Firm's investment banking business. All Firm employees, including the analyst(s) responsible for preparing this report, may be eligible to receive non-product or service specific monetary bonus compensation that is based upon various factors, including total revenues of the Firm and its affiliates as well as a portion of the proceeds from a broad pool of investment vehicles consisting of components of the compensation generated by investment banking activities, including but not limited to shares of stock and/or warrants, which may or may not include the securities referenced in this report.
Although the statements in this report have been obtained from and are based upon recognized statistical services, issuer reports or communications, or other sources that the Firm believes to be reliable, we cannot guarantee their accuracy. All opinions and estimates included in this report constitute the analyst's judgment as of the date of this report and are subject to change without notice.
Information about risks can be found in the "RISK ANALYSIS" section of this report.
The securities of the company discussed in this report may be unsuitable for investors depending on their specific investment objectives and financial position. This report is offered for informational purposes only and does not constitute an offer or solicitation to buy or sell any securities discussed herein in any jurisdiction where such would be prohibited. Additional information is available upon request.
Analyst Certification: The analyst(s) whose name appears on this research report certifies that 1) all of the views expressed in this report accurately reflect his (their) personal views about any and all of the subject securities or issuers discussed; and 2) no part of the research analyst's compensation was, is, or will be directly or indirectly related to the specific recommendations or views expressed by the research analyst in this research report; and 3) all Dawson James employees, including the analyst(s) responsible for preparing this research report, may be eligible to receive non-product or service specific monetary bonus compensation that is based upon various factors, including total revenues of Dawson James and its affiliates as well as a portion of the proceeds from a broad pool of investment vehicles consisting of components of the compensation generated by investment banking activities, including but not limited to shares of stock and/or warrants, which may or may not include the securities referenced in this report.




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