Two events pertaining to Adaptimmune Therapeutics Plc (ADAP:NASDAQ) second generation T-cell receptor program, primarily the SURPASS Phase 1 clinical trial, are scheduled for the imminent 2022 European Society for Medical Oncology (ESMO) meeting, reported ROTH Capital Partners analyst Dr. Tony Butler in a September 6, 2022 research note.
ROTH has a Buy rating and a $9 per share target price on Adaptimmune, the current share price of which is about $2.03.
Adaptimmune is developing novel immunotherapy drugs for cancer patients, and the SURPASS trial evaluated ADP-A2M4CD8, its autologous T-cell receptor T-cell therapy, in previously treated patients with unresectable or metastatic tumors.
8 a.m. EST on Sept. 9: In a virtual event, the London-based biopharma will give an update on its first SURPASS study and discuss plans for other related trials.
Also, Dr. Kathleen Moore will talk about her experience relative to the first SURPASS study and ovarian cancer. She is an associate professor of gynecologic oncology at the University of Oklahoma College of Medicine and a SURPASS investigator.
The discussions will end with a live Q&A session.
9:45 a.m. EST on Sept. 10: In a mini oral session 735MO, Dr. David S. Hong will cover updated safety and efficacy results from SURPASS Phase 1. Hong is with the Department of Investigational Cancer Therapeutics at the MD Anderson Cancer Center.
Butler reiterated general SURPASS results and what is next for the program. SURPASS showed 8 out of 22, or 36% of, patients had RECIST responses, he relayed. One patient with ovarian cancer had a complete response, while other patients, having bladder cancer, head and neck cancer, gastroesophageal cancer, and synovial sarcoma experienced a partial response.
Given these results, noted Butler, Adaptimmune is now conducting SURPASS-2, a Phase 2 trial of ADP-A2M4CD8 in esophageal or esophagogastric junction cancers.
Also, later this year, the company plans to commence another Phase 2 trial, called SURPASS-3, of ADP-A2M4CD8 in combination with a checkpoint inhibitor in ovarian cancer patients.
ROTH has a Buy rating and a $9 per share target price on Adaptimmune, the current share price of which is about $2.03.
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Disclosures For Roth Capital Partners, Adaptimmune Therapeutics PLC., September 6, 2022
ROTH makes a market in shares of Adaptimmune Therapeutics PLC and as such, buys and sells from customers on a principal basis. Shares of Adaptimmune Therapeutics PLC may be subject to the Securities and Exchange Commission's Penny Stock Rules, which may set forth sales practice requirements for certain low-priced securities.
ROTH Capital Partners, LLC expects to receive or intends to seek compensation for investment banking or other business relationships with the covered companies mentioned in this report in the next three months. The material, information and facts discussed in this report other than the information regarding ROTH Capital Partners, LLC and its affiliates, are from sources believed to be reliable, but are in no way guaranteed to be complete or accurate. This report should not be used as a complete analysis of the company, industry or security discussed in the report. Additional information is available upon request. This is not, however, an offer or solicitation of the securities discussed.
Any opinions or estimates in this report are subject to change without notice. An investment in the stock may involve risks and uncertainties that could cause actual results to differ materially from the forward-looking statements. Additionally, an investment in the stock may involve a high degree of risk and may not be suitable for all investors. No part of this report may be reproduced in any form without the express written permission of ROTH. Copyright 2022. Member: FINRA/SIPC
