In a news release, Revive Therapeutics Ltd. (RVV:TSX.V; RVVTF:OTCMKTS) announced that "it has entered into a sponsored research agreement and an exclusive option to license agreement with North Carolina State University to develop a novel biosynthetic version of psilocybin based on a natural biosynthesis enzymatic platform developed by Dr. Gavin Williams, Professor and Researcher at NC State."
The company explained that the platform Dr. Williams created "provides a potential simple and efficient method for rapidly producing natural products, such as psilocybin, using an engineered enzymatic pathway in E. coli."
Revive Therapeutics noted that it is presently seeking ways to scale production and market its own pharmaceutical-grade psilocybin. The firm has developed an oral thin film psilocybin-based product together with the University of Wisconsin-Madison using PharmaTher Inc.'s (PHRM:CSE, PHRRF:OTCQB) intellectual property and psilocybin research.
Revive Therapeutics CEO Michael Frank commented, "We are excited to partner with NC State and work with Dr. Williams and his team to develop a proprietary form of psilocybin that can be produced at scale for research and commercial purposes while allowing us to create our own unique product offerings with psilocybin in different delivery methods so as to treat the various mental health conditions and other diseases for which psilocybin has shown to be a potential viable treatment option...We continue to expand our psychedelic pharmaceutical objectives in specializing in novel products and uses of psilocybin for unmet medical needs."
The firm noted that Dr. Williams is a "decorated chemist and well known for his innovative work in polyketide biosynthesis," and that together with his team, Professor Williams recently developed an artificial enzymatic platform called the 'Alcohol Dependent Hemiterpene' (ADH) pathway for construction of alkyl pyrophosphates. Revive stated that the products biosynthesized in the ADH pathway will serve to form the basis for psilocybin and its derivatives with the objective of engineering E. coli to be a factory for psilocybin production.
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