In a news release, Revive Therapeutics Ltd. (RVV:TSX.V; RVVTF:OTCMKTS) announced that its partnership with the University of Wisconsin-Madison's Reed Research Group to evaluate novel formulations of psilocybin led to the development of orally dissolvable thin strips for delivery of it and other psychedelic-derived drugs.
"This is the first time that we have applied our drug delivery technology to oral thin films, and we see great promise in delivering psychedelic-based medicines to treat various diseases and disorders that would benefit from such a delivery method and in partnering with life sciences companies seeking to add unique offerings in their product pipeline," Revive CEO Michael Frank said.
The Ontario-based biotech firm just received the first set of these new film strips. It plans to conduct further tests on the product, such as on the delivery of varying psilocybin doses, and unveil the final prototype in the coming weeks, which will be used in future clinical trials.
Revive noted that it chose a tannin-chitosan composite of orally dissolvable thin films as the best delivery method of therapeutic doses, 1–20 milligrams, of psilocybin into the oral cavity because it offers advantages and benefits, such as "the rapid dissolving and onset of action to the bloodstream, the ease and convenience for patients to administer without the need of water, chewing or swallowing, the potential of improved therapeutic outcomes and efficacy for underserved diseases and disorders and the flexibility to create accurate dosing and tasteful options."
According to the company, "The drug delivery technology aims to deliver both synthetic and natural extract of psilocybin in a potential number of ways such as orally dissolvable thin films, topical gels, creams or ointments, oral or transdermal patches, oral dosages and foams. The delivery technology is a natural, non-toxic, biodegradable and biocompatible composite that combines a tannin material, which is derived from a plant group having antibacterial, antifungal, antioxidant and wound healing properties, and a chitosan material, which is derived from the crustacean group having blood-clotting and antimicrobial properties. The delivery technology has a rapid onset of action and controlled or sustained release potential capabilities and may allow combining multiple extracts from mushrooms in one formulation."
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