In a news release, clinical stage pharmaceutical development company Algernon Pharmaceuticals Inc. (AGN:CSE; AGNPF:OTCQB; AGW:FSE) announced that "it has received ethics approval from the Royal Brisbane & Women's Hospital, Human Research Ethics Committee for its planned Phase 2 Idiopathic Pulmonary fibrosis (IPF) and chronic cough clinical study of its re-purposed drug NP-120 (Ifenprodil), an NMDA receptor antagonist."
The firm noted that the two sites that received approval are Cairns Hospital in Queensland and Concord Repatriation General Hospital in New South Wales. The company indicated that it is still waiting to receive ethics approval for one additional location in Australia and two other participating sites in New Zealand. Algeron stated that it expects to commence enrollment in the Ifenprodil Phase 2 IPF and chronic cough clinical study in late June.
The company's CEO Christopher J. Moreau commented, "Novotech, our Asia-Pacific CRO partner, continues to meet their projected timelines for this very important study...We look forward to conclusion of the ethics approval process and announcing the enrollment of the first patient in the trial."
The firm advised that the purpose of the Phase 2 IPF & Chronic Cough Study is to determine the efficacy of Ifenprodil in the preservation of lung function in IPF patients (including biomarkers of fibrosis) and its associated cough. The company noted that "Ifenprodil has been shown to mediate anti-inflammatory responses and reduce pulmonary fibrosis in a murine model of IPF and significantly reduced both cough frequency and onset in a guinea pig tussive model."
The firm explained that "NP-120 (Ifenprodil) is an N-methyl-D-aspartate (NMDA) receptor antagonist specifically targeting the NMDA-type subunit 2B (Glu2NB) and that Ifenprodil prevents glutamate signaling." The company added that NMDA receptors are found on many tissues including lung cells and T-cells, neutrophils.
The company advised that it has already filed new intellectual property rights globally for NP-120 (Ifenprodil) for use in treatment of respiratory diseases. The firm stated that it is also presently working to develop a proprietary injectable and a slow release formulation.
Algernon Pharmaceuticals is a drug re-purposing firm headquartered in Vancouver. The company focuses on investigating safe and previously approved medicines for use in new disease applications.
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