ProMIS Neurosciences Inc. (PMN:TSX; ARFXF:OTCQB) announced in a news release it developed antagonists against the receptor for activated protein kinase C 1 (RACK1), which prevent aggregation of normal brain protein and related neuronal dysfunction that lead to neurodegenerative diseases.
RACK1, an essential protein for normal cell function, is involved in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Thus, using ProMIS' receptors to target RACK1 could play a role in treating those diseases.
"Researchers have identified RACK1 as a promising target for neurodegenerative diseases because it interacts with other physiologically important proteins including TAR DNA-binding protein 43 and fused in sarcoma, an RNA-binding protein. Both are implicated in the development of ALS," the release explained.
"The development of novel antagonists against RACK1 demonstrates the versatility of our proprietary drug discovery and development platform," stated Dr. Elliot Goldstein, ProMIS CEO. "We're using our unique technology to develop not only antibodies and other antagonists for neurodegenerative diseases, including new intrabodies that are ideal for intracellular vectorization, but also a reliable and accurate antibody test for Covid-19. Today's news is another example of how we continue to expand the utility of our platform to address a broad range of diseases in unique and highly differentiated ways."
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