RXII:NASDAQ

RXi Pharmaceuticals Corp.

RXi Pharmaceuticals Corporation is a clinical-stage company developing innovative therapeutics that address significant unmet medical needs. Building on the pioneering discovery of RNAi, the Company's discovery and clinical development programs are based on its proprietary self-delivering RNAi (sd-rxRNA®) platform and Samcyprone™, a small molecule topical immunomodulator. Current clinical development programs include RXI-109, an sd-rxRNA, for the treatment of dermal and ocular scarring, and Samcyprone™ for the treatment of such disorders as warts, alopecia areata, non-malignant skin tumors and cutaneous metastases of melanoma. RXi's robust pipeline, coupled with an extensive patent portfolio, provides for multiple product and business development opportunities across a broad spectrum of therapeutic areas. We are committed to being a partner of choice for academia, small companies, and large multinationals. We welcome ideas and proposals for strategic alliances, including in- and out-licensing opportunities, to advance and further develop strategic areas of interest.
RXII:NASDAQ

Expert Comments:

The potential of RXi Pharmaceuticals' sd-rxRNA technology in the development of cancer immunotherapies has resulted in an extension of its research collaboration with Oslo-based PCI Biotech and captured the attention of two analysts.
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Marcel Wijma, Van Leeuwenhoeck Research (5/22/17)
"RXi Pharmaceuticals Corp. announced that it has extended its existing agreement with the Norwegian biotech company PCI Biotech. This extension is supported by a new preclinical research collaboration agreement that reflect RXi's recently completed acquisition of MirImmune and PCI Biotech's focus in oncology. . .both companies will retain exclusive ownership rights to existing registered intellectual property. However, any inventions arising from the collaboration will be jointly owned by the companies. . .we have increased our valuation on RXi Pharmaceuticals to $4.50- 5.50 USD per share."

Marcel Wijma, Van Leeuwenhoeck Research (5/17/17)
"RXi Pharmaceuticals Corp. developed a robust RNAi therapeutic platform including self-delivering RNA (sd-rxRNA) compounds, that have the ability to highly selectively block the expression of any target in the genome, thus providing applicability to many therapeutic areas. . .we have increased our valuation on RXi Pharmaceuticals Corp. to USD 100-125 million or USD 4.50-5.50 per share. . .due to the fact that we have increased our likelihood of approval and market potential for RXi's lead product RXI-109. At this moment we do not address value to the preclinical programs in RXi's pipeline."

Keith Markey, Griffin Securities (5/4/17)
"RXi Pharmaceuticals Corp. added a multi-faceted oncology platform to its R&D pipeline with the January acquisition of MirImmune. Now the Company has five compounds targeting checkpoint inhibitors that should enjoy a significant cost advantage over today's antibodybased inhibitors and a sixth that is designed to prevent cytokine release syndrome. . .based on the new checkpoint inhibitors and the potential for multiple partnering deals, we believe a $6.50 price target is achievable and we are maintaining our BUY recommendation."

With the granting of a new patent in Japan for its lead compound, RXI-109, RXI Pharmaceuticals has strengthened its reach in Asian markets and enhanced the protections surrounding its proprietary RNAi platform.
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Management Q&A: View From the Top
RXi Pharmaceuticals' proprietary self-delivering RNAi (sd-rxRNA) platform offers efficient delivery to cells ex vivo, an application with tremendous potential in immuno-oncology. It's no surprise then that RXi has acquired MirImmune, a company that has been focusing on the next generation of immunotherapies for the treatment of cancer. In this interview with The Life Sciences Report, Geert Cauwenbergh, RXi's President and CEO; Alexey Eliseev, Chief Business Officer; and Pam Pavco, Chief Development Officer, discuss their technologies, the merger and why they believe that in 10 years pure chemotherapy could be relegated to the treatment of last resort.
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Marcel Wijma, Van Leeuwenhoeck Research (2/13/17)
"Based on our net present value valuation, we believe that RXi Pharmaceuticals Corp. is substantially undervalued at the current share price of $0.74. Using our valuation model and taking into account the further development of its pipeline including the acquisition of MirImmune, the company's current total value should be $75-100M, or $4.50-6/share; this represents a substantial upside from the current share price."

Donovan Jones, Seeking Alpha (12/15/16)
"RXi Pharmaceuticals Corp. secured an exclusive option to acquire MirImmune, a company developing cell-based immunotherapies for the treatment of cancers such as ovarian cancer and melanoma. . .for its lead candidate RXI-109 for the treatment of dermal scarring. . .the preliminary data showed positive differentiation between control and treated subjects after surgical incisions at all time points through nine months post-surgery. RXi expects a complete results announcement in mid-2017. . .RXII's offering is a Buy, based on a promising outlook for its leading scar treatment candidate."

Maxim Jacobs, Edison Investment Research (10/25/16)
"RXi Pharmaceuticals Corp. recently announced that it has entered into an exclusive option agreement to acquire MirImmune, an early-stage private company focusing on immune checkpoint modulation, in exchange for a share amount equal to 19.99% of RXi's outstanding stock plus milestones. . .MirImmune had licensed RXi's sd-rxRNA technology for use in cell-based cancer immunotherapy back in March 2015. . .the knockdown of these proteins should enable the CAR-T cells to recognize and engage tumor cells that are otherwise masked from the immune system via expression of checkpoint ligands."

More Expert Comments

Experts Following This Company

Maxim Jacobs, Director of Healthcare Research & Equity Analyst – Edison Investment Research
Keith Markey, Scientific Director – Griffin Securities
Marcel Wijma, Analyst – The Daily Molecule (Van Leeuwenhoeck Research), Van Leeuwenhoeck Research

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Investing Highlights
 
RXi has developed a robust, proprietary RNAi therapeutic platform
 
RNAi has the ability to “silence” a specific gene in a disease condition
 
Extensive patent estate provides for multiple development and commercialization of RNAi therapeutics